A statement by the Iraqi military's media centre said one young woman and a security officer were killed in the blast, which took place in the city's eastern half.
Ten other people were wounded.
Iraqi forces ousted the Islamic State group from Mosul in mid-2017, but explosions and hit-and-run attacks have continued to plague the province.
Last week a car bomb detonated near Mosul University, killing one person and wounding 13 more.
On Wednesday night, six paramilitary forces were killed and more than two dozen wounded in an ambush south of Mosul.
Iraqi authorities have also warned that jihadists could slip across the porous border from east Syria, where IS faces a ferocious US-backed offensive on its final redoubt.
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